Propafenone Hydrochloride Ritonavir
ModerateRitonavir blocks the liver enzymes CYP2D6 and CYP3A4, which are the ones that break down propafenone hydrochloride. Other medicines do the same thing, such as desipramine, paroxetine and sertraline (CYP2D6), amiodarone (CYP1A2), and ketoconazole, saquinavir, erythromycin and even grapefruit juice (CYP3A4). When any of these are taken with propafenone, its level in the blood can be expected to rise.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.