Xifos Ifosfamide Ketoconazole
ModerateKetoconazole can slow down the way your body converts ifosfamide into its active form, the part that actually attacks cancer cells. With less of the active form, ifosfamide may not work as well as it should. Ketoconazole works this way because it blocks CYP3A4, a liver enzyme involved in this conversion. If you have been prescribed both, tell your oncologist so they can decide how to manage it.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.