Ertinib Erlotinib Ketoconazole
ModerateKetoconazole strongly blocks CYP3A4, an enzyme the body uses to break medicines down. When it was taken together with Erlotinib, the AUC of Erlotinib went up by 67%. AUC is the total amount of a medicine in the blood over time. So the body was exposed to about two-thirds more Erlotinib than usual.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.