Flucovax 150 Fluconazole Rivaroxaban
MajorTaking fluconazole together with rivaroxaban increases the level of rivaroxaban in the body and its effects, such as factor Xa inhibition and PT prolongation. Fluconazole is a combined P-gp and CYP3A4 inhibitor, so taking these two medicines together should be avoided.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.