Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Cardiac Arrhythmia Deep Vein Thrombosis Stroke

Rafter 2.5 mg tablet is used to help prevent atherothrombotic events in adult patients following an Acute Coronary Syndrome (ACS) with elevated cardiac biomarkers (Troponin or CK-MB), and is given together with Aspirin alone or with Aspirin plus Clopidogrel or Ticlopidine. Rafter 10 to 20 mg tablet is used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation; to treat deep vein thrombosis (DVT) and pulmonary embolism (PE) and to reduce the risk of their recurrence; and for the prevention of DVT, which may lead to PE, in patients undergoing knee or hip replacement surgery.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Rivaroxaban is a highly selective agent that works by directly inhibiting factor Xa. By blocking factor Xa, it interrupts both the intrinsic and extrinsic pathways of the blood clotting cascade and reduces the formation of thrombin. It does not inhibit thrombin (activated factor II) itself, and it has not been shown to affect platelets.

Pregnancy & Breastfeeding

Rivaroxaban falls under pregnancy category C. No adequate, well-controlled studies have looked at its use in pregnant women, so a safe dosing schedule for pregnancy has not been established. Whether Rivaroxaban passes into human breast milk is also unknown, and its safety and effectiveness in breastfeeding mothers have not been established.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Rivaroxaban 2.5 mg: The recommended dose is 2.5 mg twice daily. Patients should also take a daily dose of 75 to 100 mg Aspirin, or a daily dose of 75 to 100 mg Aspirin in addition to either a daily dose of 75 mg clopidogrel or a standard daily dose of ticlopidine. Rivaroxaban 10 to 20 mg: Nonvalvular Atrial Fibrillation: For patients with Creatinine Clearance above 50 mL/min, the dose is 20 mg orally, once daily with the evening meal. For patients with Creatinine Clearance of 15 to 50 mL/min, the dose is 15 mg orally, once daily with the evening meal. Treatment of DVT and PE: 15 mg orally twice daily with food for the first 21 days for the initial treatment of acute DVT or PE. After the initial treatment period, 20 mg orally once daily with food for the remaining treatment. Prevention of recurrence of DVT and PE: 20 mg once daily with food. Prophylaxis of DVT following hip replacement surgery: 10 mg once daily for 35 days. Prophylaxis of DVT following knee replacement surgery: 10 mg once daily for 12 days. It may be taken with or without food.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.