Voxamin XR-100 Fluvoxamine Maleate Agomelatine
MajorFluvoxamine strongly blocks CYP1A2 and moderately blocks CYP2C9, which slows the breakdown of Agomelatine in the body. This can raise Agomelatine levels 60-fold (range 12-412). So Agomelatine must not be taken with fluvoxamine, or with other strong CYP1A2 blockers such as ciprofloxacin.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.