Indications
Agorest is used to treat major depressive disorder in adults. It is particularly suited to patients who have not responded to, or cannot tolerate, selective serotonin reuptake inhibitors (SSRIs). It is also used to prevent relapse of depression.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist. Binding studies indicate that agomelatine has no effect on monoamine uptake and no affinity for a, (3 adrenergic, histaminergic, cholinergic, dopaminergic and benzodiazepine receptors. Agomelatine resynchronises circadian rhythms in animal models of circadian rhythm disruption. Agomelatine increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin.
Pregnancy & Breastfeeding
Use in pregnancy: There's no clinical data yet on how agomelatine affects pregnant women, since human exposure hasn't been formally studied. Animal studies, however, haven't shown any direct or indirect harm to pregnancy, foetal or embryonal development, delivery, or development after birth. Even so, agomelatine should be prescribed to pregnant women only with caution.
Use in lactation: Whether agomelatine passes into human breast milk isn't known, though it and its breakdown products have been found in the milk of nursing rats. Because its effects on a breastfeeding baby haven't been established, breastfeeding should be stopped if treatment with agomelatine is judged necessary.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.