Rivaflo Rivaroxaban Ketoconazole
MajorTaking Rivaroxaban with Ketoconazole, a combined P-gp and CYP3A4 inhibitor, increases the level and effects of Rivaroxaban in the body, including factor Xa inhibition and PT prolongation. For this reason, taking these two medicines together should be avoided.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.