Rith Powder for Suspension Clarithromycin Rivaroxaban
MajorTaking Rivaroxaban with Clarithromycin increases the level of Rivaroxaban in the body and increases its effects (factor Xa inhibition and PT prolongation). Because Clarithromycin is a combined P-gp and CYP3A4 inhibitor, you should avoid taking these two medicines together.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.