Roxarel 10 Rivaroxaban Clarithromycin
MajorTaking Rivaroxaban with Clarithromycin increases the level of Rivaroxaban in the body and increases its effects (factor Xa inhibition and PT prolongation). Because Clarithromycin is a combined P-gp and CYP3A4 inhibitor, you should avoid taking these two medicines together.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.