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Clarithromycin

Macrolides Prescription
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Indications

Chronic Obstructive Pulmonary Disease Pneumonia Bronchitis Sinusitis Pharyngitis Tonsillitis Peptic Ulcer Helicobacter Pylori Infection Skin and Soft Tissue Infection Otitis Media

Binoclar is used for the treatment of the following conditions: acute bacterial exacerbation of chronic bronchitis in adults, acute maxillary sinusitis, community-acquired pneumonia, pharyngitis or tonsillitis, uncomplicated skin and skin structure infections, and acute otitis media in pediatric patients. It is also used for the treatment and prophylaxis of disseminated mycobacterial infections, and for the treatment of Helicobacter pylori infection and duodenal ulcer disease in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clarithromycin acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S subunit of the bacterial ribosome and preventing translocation to that site. Clarithromycin is active against most Gram-positive bacteria and Chlamydia, some Gram-negative bacteria and Mycoplasmas. Clarithromycin's activity is the same as, or greater than, that of Erythromycin in vitro against most Gram-positive bacteria. Clarithromycin is more acid-stable than Erythromycin and therefore, is better tolerated. Clarithromycin has twice the activity of Erythromycin against H. influenzae. Most species of Gram-negative bacteria are resistant to Clarithromycin because of failure to penetrate the target.

Pregnancy & Breastfeeding

Neonates and children can receive Clarithromycin, with the dose adjusted appropriately for the individual case. If a mother is being treated with Clarithromycin, her breast milk should not be given to her infant until the course of treatment is finished. Experience with Clarithromycin in pregnant patients remains limited, so its use in pregnancy is not recommended.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults: For an acute bacterial exacerbation of chronic bronchitis, the usual dose is 250 mg to 500 mg every 12 hours for 7 to 14 days. For acute maxillary sinusitis, 500 mg is given every 12 hours for 14 days. For community-acquired pneumonia, the dose is 250 mg every 12 hours for 7 to 14 days. For pharyngitis or tonsillitis, 250 mg is given every 12 hours for 10 days. For uncomplicated skin and skin structure infections, the dose is 250 mg every 12 hours for 7 to 14 days. For treatment and prophylaxis of disseminated Mycobacterium avium disease, 500 mg is given every 12 hours until the patient is considered at low risk of disseminated infection. Combination dosing regimens for H. pylori infection are as follows. In triple therapy with clarithromycin, lansoprazole and amoxicillin, the recommended adult dosage is 500 mg clarithromycin, 30 mg lansoprazole and 1 g amoxicillin, all given every 12 hours for 10 or 14 days. In triple therapy with clarithromycin, omeprazole and amoxicillin, the recommended adult dosage is 500 mg clarithromycin, 20 mg omeprazole and 1 g amoxicillin, all given every 12 hours for 10 or 14 days. In patients who have an ulcer present at the start of therapy, an additional 14 or 18 days of omeprazole 20 mg once daily is recommended for ulcer healing and symptom relief. In dual therapy with clarithromycin and omeprazole, the recommended adult dosage is 500 mg clarithromycin given every 8 hours and 40 mg omeprazole given once every morning for 14 days, with an additional 14 days of omeprazole 20 mg once daily recommended for ulcer healing and symptom relief. Children: The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days. For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours, up to 500 mg every 12 hours. Renal and hepatic impairment: Clarithromycin is excreted principally via the liver and kidney. It may be administered without dosage adjustment to patients with hepatic impairment and normal renal function. However, in the presence of severe renal impairment, with or without coexisting hepatic impairment, a decreased dose or prolonged dosing interval may be appropriate.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.