Opifen Fentanyl Citrate Ketoconazole
ModerateKetoconazole is one of several medicines, along with other antifungals, macrolide antibiotics and CNS depressant drugs, that can affect how fentanyl works. The others named are itraconazole, troleandomycin, clarithromycin, nelfinavir and nefazadone. If you take ketoconazole together with fentanyl (Durogesic), the effects of fentanyl may become stronger or last longer than expected.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.