Melatonin (Filfresh) may make fluoxetine work less well. If you take both, your depression treatment may not control your symptoms as well as it should. Talk to your doctor before combining them, and don't stop or change your fluoxetine dose on your own.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.