Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Osteoporosis Insomnia Schizophrenia

Filfresh is used for numerous conditions, but it shows the most promise in the short-term regulation of sleep patterns, including jet lag. In insomnia, Filfresh helps to induce sleep in people with disrupted circadian rhythms (such as those suffering from jet lag or poor vision, or those who work the night shift), in people with low melatonin levels (such as some elderly people and individuals with schizophrenia), and in children with learning disabilities who suffer from insomnia. In osteoporosis, Filfresh stimulates cells called osteoblasts, which promote bone growth. In menopause, Filfresh helps peri- or postmenopausal women to regulate their sleep patterns. In eating disorders, melatonin levels may play a role in the symptoms of anorexia. In attention deficit hyperactivity disorder (ADHD), it may be effective in managing sleep disturbances in children with this condition. It is also used in sarcoidosis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

After administration, melatonin binds with its receptors. Two types of melatonin receptor subtypes, MT1 and MT2, have been identified in humans. Melatonin receptors are found in the brain and some peripheral organs. The MT1 subtype is present in the pars tuberalis of the pituitary gland and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype is mainly present in the retina. Increased levels of melatonin initiate neural and endocrine signals to optimize the levels of neurotransmitters, for example, increased serotonin, increased GABA, and decreased dopamine, which induce and sustain sleep, as well as maintain the body's circadian rhythm.

Pregnancy & Breastfeeding

Not enough safety and effectiveness data exist on using melatonin during pregnancy or while breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults: For insomnia, take 3 to 6 mg one hour before bedtime. For jet lag, take 0.50 to 5 mg one hour before bedtime at the final destination, or take 1 to 5 mg one hour before bedtime for 2 days before departure and for 2 to 3 days after arriving at the final destination. For eastbound travel, take one dose in the early evening before the flight, then take a dose at bedtime for 4 days after arrival. For westbound travel, take a dose at bedtime for 4 days once in the new time zone. For sarcoidosis, take 20 mg per day for 4 to 12 months. For depression, take 0.125 mg twice in the late afternoon, with the two doses 4 hours apart. For difficulty falling asleep, take 5 mg 3 to 4 hours before the planned sleep period, continued over a 4-week period. Children (6 months to 14 years of age): For sleep disorders, give 0.30 mg per day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.