In women with osteoporosis after menopause, Denosis (denosumab, 60 mg injection under the skin) did not change how the body handles midazolam. Midazolam is broken down by an enzyme in the liver called cytochrome P450 3A4 (CYP3A4). This suggests that denosumab should not affect other medicines broken down by this same enzyme, at least in this group of patients.
Little or no effect is expected. You usually do not need to change anything, but still tell your doctor or pharmacist about every medicine you take.