Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Insomnia

Sedaquil is used for the short-term treatment of insomnia, and for sedation as premedication before surgical or diagnostic procedures.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Benzodiazepines such as midazolam work by acting on gamma-aminobutyric acid (GABA), one of the main inhibitory neurotransmitters in the central nervous system. They increase the activity of GABA, which produces a calming, sedative effect, relaxes the skeletal muscles, and brings on sleep, anesthesia, and memory loss (amnesia). Midazolam does this by attaching to the benzodiazepine site on GABA-A receptors, which strengthens the effect of GABA by making chloride channels open more often. These receptors are found in various body tissues, including the heart and skeletal muscle, but they are concentrated mainly in the central nervous system.

Pregnancy & Breastfeeding

Midazolam is generally avoided during pregnancy unless no safer option is available. It also passes into breast milk, so breastfeeding mothers should not take it.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oral dosage. For adults, the usual dose is 7.5 to 15 mg daily. For elderly and debilitated patients, the recommended dose is 7.5 mg. For premedication, 15 mg of midazolam should be given 30 to 60 minutes before the procedure. Intravenous administration. For endoscopic or cardiovascular procedures in healthy adults, the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg. For induction of anesthesia, the dose is 10 to 15 mg. Intramuscular administration. For adults, the dose is 0.07 to 0.1 mg per kg of body weight, and the usual dose is about 5 mg. For children, the dose is 0.15 to 0.20 mg per kg. For elderly and debilitated patients, the dose is 0.025 to 0.05 mg per kg. Rectal administration in children. For preoperative sedation, the ampoule solution is given rectally at 0.35 to 0.45 mg per kg, 20 to 30 minutes before induction of general anesthesia.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.