Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
বাং
Community data Updated 2 months ago
🌐 বাংলায় দেখুন

Indications

Fungal Infection

Voritec is an azole antifungal medicine indicated for patients 12 years of age and older for the treatment of invasive aspergillosis; candidemia (in patients without neutropenia) and disseminated candidiasis affecting the skin, abdomen, kidney, bladder wall, and wounds; esophageal candidiasis; and serious infections caused by Scedosporium apiospermum and Fusarium species, including Fusarium solani. It is also indicated for patients who are intolerant of, or whose infection is refractory to, other antifungal therapy.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Voriconazole is a triazole antifungal used to treat serious fungal infections. It works by blocking a fungal enzyme called CYP450-dependent 14-alpha sterol demethylase, which the fungus needs to produce ergosterol, a key component of its cell membrane. By inhibiting this enzyme, voriconazole depletes ergosterol in the fungal cell membrane, disrupting its integrity and stopping the fungus from growing.

Pregnancy & Breastfeeding

No adequate, well-controlled studies exist in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oral-Voriconazole tablet and powder for suspension are to be taken at least one hour before or one hour following a meal: At or over 40 kg body weight: Loading dose regimen is 400 mg or 10 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 200 mg or 5 ml twice daily. Below 40 Kg body weight: Loading dose regimen is 200 mg or 5 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 100 mg or 2.5 ml twice daily. Or, as directed by the registered physician. Injection-Invasive Aspergillosisd: Loading dose: 6 mg/kg 12 hourly for the first 24 hours. Maintenance Dose: 4 mg/kg 12 hourly. Candidemia in nonneutropenic patients and other deep tissue Candida infections: Loading dose: 6 mg/kg 12 hourly for the first 24 hours. Maintenance Dose: 3-4 mg/kg 12 hourly. Scedosporiosis and Fusariosis: Loading dose: 6 mg/kg 12 hourly for the first 24 hours. Maintenance Dose: 4 mg/kg 12 hourly.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.