Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Type 2 Diabetes Mellitus Type 1 Diabetes Mellitus Diabetes Mellitus

Monotherapy and Combination Therapy: Glyza tablet is used along with diet and exercise to help control blood sugar levels in adults with type 2 diabetes mellitus. Limitation of Use: Glyza tablet is not suitable for treating type 1 diabetes mellitus or diabetic ketoacidosis, as it is not effective in these conditions.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Saxagliptin is an orally active inhibitor of the DPP4 enzyme. It works by competitively blocking DPP4, which slows the breakdown of incretin hormones. This raises their levels in the bloodstream and, in a glucose-dependent manner, lowers both fasting and after-meal (postprandial) glucose concentrations in people with type 2 diabetes mellitus.

Pregnancy & Breastfeeding

Pregnancy Category B. Well-controlled studies in pregnant women are lacking, so, as with other antidiabetic medicines, Saxagliptin should be used in pregnancy only when clearly necessary. Whether Saxagliptin passes into human breast milk is not known; since many medicines do pass into breast milk, it should be used with caution in nursing mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The recommended dose is 2.5 mg or 5 mg once daily, taken without regard to meals. Patients with Renal Impairment: No dosage adjustment is recommended for patients with mild renal impairment (creatinine clearance >50 mL/min). For patients with moderate or severe renal impairment, or with end-stage renal disease (ESRD) requiring hemodialysis (creatinine clearance <50 mL/min), the dose is 2.5 mg once daily. Saxagliptin should be administered following hemodialysis. Saxagliptin has not been studied in patients undergoing peritoneal dialysis. Because the dose of Saxagliptin should be limited to 2.5 mg based on renal function, assessment of renal function is recommended before starting Saxagliptin and periodically thereafter. Renal function can be estimated from serum creatinine using the Cockcroft-Gault formula or the Modification of Diet in Renal Disease formula.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.