Pricing
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Sixtin is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose is 2.5 mg or 5 mg once daily, taken without regard to meals. Patients with Renal Impairment: No dosage adjustment is recommended for patients with mild renal impairment (creatinine clearance >50 mL/min). For patients with moderate or severe renal impairment, or with end-stage renal disease (ESRD) requiring hemodialysis (creatinine clearance <50 mL/min), the dose is 2.5 mg once daily. Saxagliptin should be administered following hemodialysis. Saxagliptin has not been studied in patients undergoing peritoneal dialysis. Because the dose of Saxagliptin should be limited to 2.5 mg based on renal function, assessment of renal function is recommended before starting Saxagliptin and periodically thereafter. Renal function can be estimated from serum creatinine using the Cockcroft-Gault formula or the Modification of Diet in Renal Disease formula.
Side Effects
Adverse reactions occurred in more than 5% of patients taking Glyza, and more often than with placebo, included upper respiratory tract infection, urinary tract infection, and headache. Swelling of the hands, ankles, or feet (peripheral edema) was more common when Glyza was combined with a thiazolidinedione (TZD) than with placebo plus a TZD. Low blood sugar (hypoglycemia) occurred more often when Glyza was combined with a sulfonylurea than with placebo plus a sulfonylurea. Allergic-type reactions, such as hives or swelling of the face, were also reported more frequently with Glyza than with placebo.
Cautions & Contraindications
Warnings & Precautions
Dosage adjustment of Glyza isn't needed when it's taken alongside rifampin, diltiazem, amprenavir, aprepitant, erythromycin, fluconazole, fosamprenavir, grapefruit juice, or verapamil. However, if it's given together with ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, or telithromycin, the Glyza dose should be limited to 2.5 mg.
Contraindications
Saxagliptin should not be used by anyone who has previously had an allergic reaction to it.