Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Schizophrenia Bipolar Disorder

Risperdex tablet is indicated for the treatment of acute and chronic psychoses, mania and schizophrenia.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Risperidone is a selective monoaminergic antagonist that binds with high affinity to serotoninergic 5-HT2 and dopaminergic D2 receptors. It also binds to alpha1 adrenergic receptors, and with lower affinity to H1 histamine and alpha2 adrenergic receptors, while showing no affinity for 8 cholinergic receptors. As a potent D2 antagonist, risperidone improves the positive symptoms of schizophrenia while causing less depression of motor activity. Its balanced antagonism of central serotonin and dopamine may lower the risk of extrapyramidal side effects and extend its therapeutic benefit to the negative and affective symptoms of schizophrenia as well.

Pregnancy & Breastfeeding

In experimental animals, Risperidone did not cause direct reproductive toxicity, although some indirect effects mediated through prolactin and the CNS were observed. No study has found any teratogenic effect of Risperidone. The safety of Risperidone during human pregnancy has not been established. Animal studies show that Risperidone and 9-hydroxyrisperidone pass into breast milk, and this has also been demonstrated in human breast milk. For this reason, women taking Risperidone should not breastfeed.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Psychoses: 2 mg in 1 to 2 divided doses on the first day, then 4 mg in 1 to 2 divided doses on the second day (slower titration is appropriate in some patients). The usual dose range is 4 to 6 mg daily. Doses above 10 mg daily should be used only if the benefit is considered to outweigh the risk (maximum 16 mg daily). Elderly patients, or those with hepatic or renal impairment, should start with 1 mg daily in two divided doses, increased in steps of 1 to 2 mg twice daily. Not recommended for children under 15 years. Mania: Initially 2 mg once daily, increased if necessary in steps of 1 mg daily. The usual dose range is 1 to 6 mg daily. Elderly patients, or those with hepatic or renal impairment, should start with 1 mg daily in two divided doses, increased in steps of 1 to 2 mg twice daily. Schizophrenia: Risperidone should generally be started at 1 mg BID (twice daily), with increases in increments of 1 mg BID on the second and third day, as tolerated, to reach a target dose of 3 mg BID by the third day. Further dosage adjustments, if indicated, should generally be made at intervals of not less than 1 week. When dosage adjustments are necessary, small increments or decrements of 1 to 2 mg are recommended.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.