Rabeprazole Sodium

Adults: Dosage Active Duodenal Ulcer and Active Benign Gastric Ulcer: For both active duodenal ulcer and active benign gastric ulcer, the recommended oral dose is 20 mg taken once daily in the morning. Most patients with active duodenal ulcer heal within four weeks, though a few may need an additional four weeks of therapy to achieve healing. Most patients with active benign gastric ulcer heal within six weeks, though again a few may need an additional six weeks of therapy to achieve healing. Erosive or Ulcerative Gastro-Esophageal Reflux Disease (GERD): The recommended oral dose for this condition is 20 mg taken once daily for four to eight weeks. Gastro-Esophageal Reflux Disease Long-term Management (GERD Maintenance): For long-term management, a maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily can be used depending on patient response. Symptomatic Treatment of Moderate to Very Severe Gastro-Esophageal Reflux Disease (Symptomatic GERD): 10 mg once daily in patients without oesophagitis. If symptom control has not been achieved within four weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using an on demand regimen, taking 10 mg once daily as needed. Treatment of GERD in Pediatric Patients 1 to 11 Years of Age (Less than 15 kg): 5 mg once daily for 12 weeks, with the option to increase to 10 mg if the response is inadequate. Treatment of GERD in Pediatric Patients 1 to 11 Years of Age (15 kg or More): 10 mg once daily for 12 weeks. Zollinger Ellison Syndrome: The recommended adult starting dose is 60 mg once a day. The dose may be titrated upwards to 120 mg per day based on individual patient needs. Single daily doses up to 100 mg per day may be given. A 120 mg dose may require divided dosing, given as 60 mg twice daily. Treatment should continue for as long as clinically indicated. Eradication of H. pylori: Patients with H. pylori infection should be treated with eradication therapy. The following combination given for 7 days is recommended: rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1 g twice daily.