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Community data Updated 2 months ago

Pyridoxine Hydrochloride

Vitamin-B preparations Prescription
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Indications

Epilepsy Depression

Pyrovit is indicated in- Treatment and prevention of pyridoxine deficiency states Sideroblastic anaemias Seizures due to hereditary syndromes of pyridoxine deficiency or dependency in infants Depression and other symptoms associated with premenstrual syndrome & the use of oral contraceptives. Prophylaxis of isoniazid-induced peripheral neuritis and for the treatment of acute isoniazid toxicity.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Vitamin B6 (pyridoxine) is a water-soluble vitamin used to prevent and treat vitamin B6 deficiency and the peripheral neuropathy that can occur in people taking isoniazid (isonicotinic acid hydrazide, INH). In a small group of subjects with essential hypertension, vitamin B6 was found to lower both systolic and diastolic blood pressure. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study, again in a small group of subjects, showed that pyridoxine hydrochloride inhibits ADP or epinephrine induced platelet aggregation and lowers total cholesterol while raising HDL cholesterol. Vitamin B6, in the form of pyridoxal 5'-phosphate, was also found to protect cultured vascular endothelial cells from injury caused by activated platelets. Endothelial injury and dysfunction are critical initiating events in the development of atherosclerosis. Human studies have shown that vitamin B6 deficiency affects both the cellular and humoral responses of the immune system. Such deficiency can alter lymphocyte differentiation and maturation, reduce delayed type hypersensitivity (DTH) responses, impair antibody production, and lower lymphocyte proliferation and interleukin (IL) 2 production, among other immunologic effects.

Pregnancy & Breastfeeding

Pyridoxine needs tend to rise during pregnancy, and it is sometimes useful for easing pregnancy-related nausea and vomiting. Requirements also increase during breastfeeding, so pyridoxine should be given to a nursing mother with caution.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oral use. For general deficiency states, up to 150 mg (6 tablets) daily. For sideroblastic anaemias, up to 400 mg (16 tablets) daily. For premenstrual syndrome, 50 to 100 mg (2 to 4 tablets) daily. For peripheral neuritis, prophylaxis is 10 to 50 mg (2 tablets) daily, and treatment is 100 to 200 mg (4 to 8 tablets) daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.