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These brands contain the same active ingredient (Pyridoxine Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Pyrol is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oral use. For general deficiency states, up to 150 mg (6 tablets) daily. For sideroblastic anaemias, up to 400 mg (16 tablets) daily. For premenstrual syndrome, 50 to 100 mg (2 to 4 tablets) daily. For peripheral neuritis, prophylaxis is 10 to 50 mg (2 tablets) daily, and treatment is 100 to 200 mg (4 to 8 tablets) daily.
Side Effects
Taking pyridoxine in large doses (more than about 2 g a day) over a long period has been linked to severe peripheral neuropathy (nerve damage in the hands and feet). Very high doses may also lower folate levels in the blood.
Cautions & Contraindications
Warnings & Precautions
Pyridoxine (Pyrovit) can reduce the effectiveness of levodopa; however, this interaction does not occur when levodopa is given together with a dopa decarboxylase inhibitor. A number of medicines may affect how pyridoxine is metabolised or absorbed, including isoniazid, penicillamine and oral contraceptives.
Contraindications
Pyridoxine should not be given to patients who are receiving levodopa for Parkinson's disease. At doses of 80 to 400 mg daily, pyridoxine has been reported to increase the hepatic metabolism of phenobarbitone or phenytoin by 40 to 50% in some patients, which lowers the serum concentration of these drugs.