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Community data Updated 2 months ago

Prednisolone

Glucocorticoids Prescription
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Indications

Osteoarthritis Rheumatoid Arthritis

Pedipred is used to treat rheumatic disorders, including psoriatic arthritis, rheumatoid arthritis (including the juvenile form), ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, and post-traumatic osteoarthritis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Prednisolone is a synthetic adrenocortical drug with predominantly glucocorticoid properties. It works by directly inhibiting the Phospholipase A2 enzyme, which is responsible for producing inflammatory mediators such as leukotrienes, SRS A, and prostaglandins. Taken orally, prednisolone is absorbed rapidly and well from the GI tract. In the plasma, it is 70 to 90% protein bound and has an elimination half life of 2 to 4 hours. It is metabolized mainly in the liver and excreted in the urine.

Pregnancy & Breastfeeding

Not recommended for use during pregnancy unless your doctor considers it essential. It should be used only if the expected benefit to the mother clearly outweighs any possible risk to the unborn baby. Corticosteroids do pass into breast milk and may slow the baby's growth, affect the body's own natural corticosteroid production, or cause other unwanted effects.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adult Nephrotic Syndrome: Initial dose is 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times per day until the urine is protein free for 3 consecutive days (maximum 28 days), followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks. Maintenance dose: 0.5 to 1 mg/kg/dose given every other day for 3 to 6 months. Anti-inflammatory: 5 to 60 mg per day in divided doses 1 to 4 times per day. Acute Asthma: 40 to 60 mg/day PO as a single daily dose or divided every 12 hours for 3 to 10 days. Allergic Conditions: Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime. Day 2: 5 mg PO before breakfast, after lunch, and after dinner, and 10 mg at bedtime. Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime. Day 4: 5 mg PO before breakfast, after lunch, and at bedtime. Day 5: 5 mg PO before breakfast and at bedtime. Day 6: 5 mg PO before breakfast. Pediatric Asthma: Under 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day. 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day. 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day. Over 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day. Anti-inflammatory: 0.05 to 2 mg/kg/day divided into 1 to 4 doses per day. Immunosuppression: 0.05 to 2 mg/kg/day divided into 1 to 4 doses per day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.