Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Epilepsy

D-Toin is an anticonvulsant used to treat status epilepticus of the grand mal type. It may also be used to prevent and treat seizures that occur during neurosurgery.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Phenytoin works as an anticonvulsant by promoting sodium ion efflux and limiting sodium ion influx across cell membranes in the motor cortex during nerve impulse generation. This stabilises neuronal membranes and reduces seizure activity. It also has antiarrhythmic effects, prolonging the effective refractory period, suppressing automaticity in the ventricular pacemaker, and shortening the heart's action potential.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults: The starting dose is 200 mg (2 tablets) daily, increased to 400 mg daily in divided doses, up to a maximum of 600 mg per day. Alternatively, 3 to 4 mg/kg daily may be given in divided doses. For adults who have not received any previous medication, the usual treatment is one tablet three times daily, or as directed by the physician. Children: The initial dose is 5 mg/kg per day, given in two or three equally divided doses. The dose is then adjusted for the individual child, up to a maximum of 300 mg daily. The recommended daily maintenance dose is usually 4 to 8 mg/kg. Children over 6 years of age require the minimum adult dose of 300 mg per day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.