Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Neuropathic Pain Headache Pain Fever Low Back Pain Viral Infection Menstrual Disorder

Pamix relieves fever, colds and flu, headache, toothache, earache, body aches, muscle and nerve pain, menstrual cramps, sprains, colic, back pain, and pain following surgery, childbirth or vaccination in children, as well as inflammatory pain. It also eases rheumatic and osteoarthritic pain and joint stiffness.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Paracetamol produces analgesia by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat regulating centre. Its weak anti inflammatory activity is related to inhibition of prostaglandin (PG) synthesis in the CNS.

Paracetamol (acetaminophen) is thought to act primarily in the CNS, raising the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, along with COX-3, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, paracetamol does not inhibit cyclooxygenase in peripheral tissues, so it has no peripheral anti inflammatory effect. Aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, but studies have found that paracetamol blocks COX indirectly, and that this blockade is ineffective in the presence of peroxides. This may explain why paracetamol is effective in the central nervous system and in endothelial cells but not in platelets and immune cells, which carry high levels of peroxides. Studies also suggest that paracetamol selectively blocks a variant of the COX enzyme distinct from the known COX-1 and COX-2 variants. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, and further research may offer more insight into how it works. The antipyretic properties of paracetamol are likely due to a direct effect on the heat regulating centre of the hypothalamus, resulting in peripheral vasodilation, sweating, and consequent heat loss.

Pregnancy & Breastfeeding

Epidemiological studies during human pregnancy have not shown any harmful effects when Paracetamol is used at the recommended dose, though patients should still follow their doctor's advice about using it. Paracetamol does pass into breast milk, but only in amounts too small to be clinically significant, and the published data available do not point to any reason to avoid breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Tablet: Adult: 1 to 2 tablets every 4 to 6 hours, up to a maximum of 4 gm (8 tablets) daily. Children (6-12 years): half to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day. Extended Release Tablet: Adults and children over 12 years: two tablets, swallowed whole, every 6 to 8 hours, up to a maximum of 6 tablets in any 24 hours. The tablet must not be crushed. Syrup/Suspension: Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily. 3 months to below 1 year: half to 1 teaspoonful 3 to 4 times daily. 1 to 5 years: 1 to 2 teaspoonful 3 to 4 times daily. 6 to 12 years: 2 to 4 teaspoonful 3 to 4 times daily. Adults: 4 to 8 teaspoonful 3 to 4 times daily. Suppository: Children 3 to 12 months: 60 to 120 mg, 4 times daily. Children 1 to 5 years: 125 to 250 mg 4 times daily. Children 6 to 12 years: 250 to 500 mg 4 times daily. Adults and children over 12 years: 0.5 to 1 gm 4 times daily. Paediatric Drop: Children upto 3 months: 0.5 ml (40 mg); 4 to 11 months: 1.0 ml (80 mg); 7 months to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 doses daily for a maximum of 5 days. Tablet with actizorb technology: it dissolves up to five times faster than standard Paracetamol tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, cannot tolerate aspirin or other analgesics. Adults and children (aged 12 years and over): take 1 to 2 tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours. Children (7 to 11 years): take half to 1 tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years. IV Infusion: Adults and adolescents weighing 50 kg and over: the recommended dosage of Paracetamol IV is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Paracetamol IV of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Paracetamol of 4000 mg per day. Adults and adolescents weighing under 50 kg: the recommended dosage of Paracetamol IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Paracetamol IV of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Paracetamol of 75 mg/kg per day. Children over 2 to 12 years of age: the recommended dosage of Paracetamol IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Paracetamol IV of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Paracetamol of 75 mg/kg per day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.