Indications
Panalon is used alongside general anesthesia during surgery. It helps relax the skeletal muscles and makes it easier to insert a breathing tube into the windpipe, and its effect is suited to operations of medium to long duration.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Pancuronium is a typical nondepolarizing, curare-mimetic muscle relaxant. It works as a competitive acetylcholine antagonist at the neuromuscular junction, displacing acetylcholine from the nicotinic acetylcholine receptors on the post-synaptic membrane. Unlike suxamethonium, it is a nondepolarizing agent, meaning it does not trigger spontaneous depolarisation when it binds to the nicotinic receptor at the neuromuscular junction, and so produces no muscle fasciculations on administration. Pancuronium has no hormonal activity. It has slight vagolytic activity (that is, it dampens vagus nerve activity) and no ganglioplegic activity (it does not block ganglia).
Nondepolarizing neuromuscular blocking agents work by competing with acetylcholine for the cholinergic receptors of the motor end plate, reducing the end plate's response to acetylcholine. This type of neuromuscular block can usually be reversed with anticholinesterase agents.
Pregnancy & Breastfeeding
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.