Oxytocin

Adults: Induction of labor and stimulation of uterine contractions: Oxytocin should be given by intravenous infusion under adequate control, with 1 to 5 IU added to 500 ml of infusion fluid. Administration is started at 1 mU per minute (1 mU equals 0.001 IU). Depending on the response, the dose can be doubled every 30 to 45 minutes until the uterine threshold is reached, generally below 10 mU per minute; a further small increase beyond this point usually provides optimal activity. Note: Intramuscular administration of Oxytocin may cause an irregular response and symptoms of overdosage. If intramuscular use cannot be avoided, the dose should not exceed 0.5 to 1 IU per injection. For the post delivery period, to prevent or treat secondary haemorrhage and adherent placenta: an intramuscular injection of 2 to 5 IU, or an intravenous infusion at an adequate dose. To stimulate lactation, and only on the advice of a registered gynaecologist or physician: an intramuscular injection of 2 IU. For treatment of incomplete abortion, to bring about more rapid expulsion and prevent secondary haemorrhage: an intramuscular injection of 2 to 5 IU every 30 to 60 minutes, or an intravenous infusion at an adequate dose.