Indications & Uses
Ocin is indicated in- Induction of labor, stimulation of uterine contractions. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta. To stimulate lactation, only it advised by the registered Gynaecologist/Physician. Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Induction of labor and stimulation of uterine contractions: Oxytocin should be given by intravenous infusion under adequate control, with 1 to 5 IU added to 500 ml of infusion fluid. Administration is started at 1 mU per minute (1 mU equals 0.001 IU). Depending on the response, the dose can be doubled every 30 to 45 minutes until the uterine threshold is reached, generally below 10 mU per minute; a further small increase beyond this point usually provides optimal activity. Note: Intramuscular administration of Oxytocin may cause an irregular response and symptoms of overdosage. If intramuscular use cannot be avoided, the dose should not exceed 0.5 to 1 IU per injection. For the post delivery period, to prevent or treat secondary haemorrhage and adherent placenta: an intramuscular injection of 2 to 5 IU, or an intravenous infusion at an adequate dose. To stimulate lactation, and only on the advice of a registered gynaecologist or physician: an intramuscular injection of 2 IU. For treatment of incomplete abortion, to bring about more rapid expulsion and prevent secondary haemorrhage: an intramuscular injection of 2 to 5 IU every 30 to 60 minutes, or an intravenous infusion at an adequate dose.
Side Effects
Hypersensitivity to Oxytocin may cause the uterus to become overly tight or tense, go into spasm, contract abnormally hard, or, rarely, rupture. Doctors also watch for increased blood loss and a drop in blood clotting factor (fibrinogen) while the drug is being given. Severe water intoxication, with convulsions and coma, has been reported in rare cases. Ocin may occasionally cause nausea, vomiting, bleeding, irregular heartbeats, or an allergic (anaphylactic) reaction. Very rarely, signs of water intoxication may appear. Use of Ocin has also been linked to a higher rate of newborn jaundice (icterus neonatorum).
Cautions & Contraindications
Warnings & Precautions
Since uterine sensitivity to Oxytocin varies considerably from patient to patient, it should be used cautiously. The smallest dose that produces an effective response should be identified for each patient and used to initiate labor. Oxytocin should be given only under adequate medical supervision, with fetal heart rate and maternal blood pressure monitored throughout. Caution is also advised where scarring of the uterus or cervix is present.
Contraindications
Cephalo-pelvic disproportion. An abnormal position of the baby or of the foetal skull. Overdistension of the lower segment of the uterus. Severe toxaemia. Hypertonic uterine dysfunction. Foetal distress where delivery is not imminent, since uterine contractions may worsen the lack of oxygen. Cord presentation and cord prolapse. Total placenta praevia. Vasa praevia.