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Oxymorphone Hydrochloride

Opioid analgesics Prescription
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Indications

Pain Low Back Pain Anxiety Cancer Edema

O-Morphon Tablet is used to treat moderate to severe pain, such as pain from chronic cancer, arthritis, surgery, or the lower back. O-Morphon Injection relieves moderate to severe pain. It is also used before and after surgery to support anesthesia, for pain relief during childbirth, and to ease anxiety in patients with breathing difficulty caused by fluid in the lungs from acute left-sided heart failure.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Oxymorphone is an opioid agonist, and its main therapeutic effect is pain relief. As with all pure opioid agonist analgesics, higher doses bring greater pain relief, with no ceiling on the analgesic effect. This differs from mixed agonist/antagonist opioids or non-opioid analgesics, where pain relief plateaus even as the dose is increased. When given by injection, 1 mg of Oxymorphone Hydrochloride provides analgesia roughly equivalent to 10 mg of Morphine sulfate.

Pregnancy & Breastfeeding

Pregnancy Category C. Whether Oxymorphone is safe to use during pregnancy has not been established, and its potential effects on the developing fetus are unknown. Because of this, Oxymorphone should only be used during pregnancy, while breastfeeding, or in women who may become pregnant if the potential benefits to the mother are judged to outweigh the potential risks to her and the child.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oxymorphone Tablet: This may be used as needed to treat acute post-surgical pain, at a dose of 5 to 10 mg every 4 hours. Take Oxymorphone Tablet on an empty stomach, at least one hour before or two hours after eating. Oxymorphone Injection: For subcutaneous or intramuscular administration, the initial dose is 1 mg to 1.5 mg, repeated every 4 to 6 hours as needed. For intravenous administration, the initial dose is 0.5 mg. For pain relief during labor, 0.5 mg to 1 mg given intramuscularly is recommended. Converting from Oral Oxymorphone to Oxymorphone Injection: Since oral Oxymorphone has an absolute bioavailability of approximately 10%, patients may be switched from oral Oxymorphone to Oxymorphone Hydrochloride injection by giving one-tenth of the patient's total daily oral Oxymorphone dose as Oxymorphone Hydrochloride injection, split into four or six equal doses (that is, the total daily oral dose divided by 10, then by 4). For example, a patient on a total daily oral dose of 40 mg of Oxymorphone may need about 1 mg of Oxymorphone Hydrochloride injection given intramuscularly every 6 hours (4 mg total daily IM dose) for equivalent pain relief. As with any opioid medicine, the dosing regimen should be adjusted for each patient individually, taking into account their prior experience with pain-relief treatment.