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Other brands with the same active ingredient
These brands contain the same active ingredient (Oxymorphone Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Narco 10 is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oxymorphone Tablet: This may be used as needed to treat acute post-surgical pain, at a dose of 5 to 10 mg every 4 hours. Take Oxymorphone Tablet on an empty stomach, at least one hour before or two hours after eating. Oxymorphone Injection: For subcutaneous or intramuscular administration, the initial dose is 1 mg to 1.5 mg, repeated every 4 to 6 hours as needed. For intravenous administration, the initial dose is 0.5 mg. For pain relief during labor, 0.5 mg to 1 mg given intramuscularly is recommended. Converting from Oral Oxymorphone to Oxymorphone Injection: Since oral Oxymorphone has an absolute bioavailability of approximately 10%, patients may be switched from oral Oxymorphone to Oxymorphone Hydrochloride injection by giving one-tenth of the patient's total daily oral Oxymorphone dose as Oxymorphone Hydrochloride injection, split into four or six equal doses (that is, the total daily oral dose divided by 10, then by 4). For example, a patient on a total daily oral dose of 40 mg of Oxymorphone may need about 1 mg of Oxymorphone Hydrochloride injection given intramuscularly every 6 hours (4 mg total daily IM dose) for equivalent pain relief. As with any opioid medicine, the dosing regimen should be adjusted for each patient individually, taking into account their prior experience with pain-relief treatment.
Side Effects
Respiratory depression, fatigue, and asthenia may occur as general disorders. Metabolism and nutrition disorders can include anorexia. Cardiac disorders such as tachycardia, bradycardia, and palpitations have been reported, along with eye disorders like miosis, diplopia, and blurred vision. Gastrointestinal disorders may present as vomiting and constipation. Psychiatric disorders associated with this medicine include dysphoria, euphoric mood, nervousness, restlessness, insomnia, agitation, hallucination, and depression. Vascular disorders such as hypotension and flushing have also been observed.
Cautions & Contraindications
Warnings & Precautions
Opioid analgesics should be used with caution especially when combined with other drugs. O-Morphon should be used with caution in elderly and debilitated patients and in patients who are known to be sensitive to central nervous system depressants such as those with cardiovascular, pulmonary, renal or hepatic disease. O-Morphon should be used with caution in the following conditions: acute alcoholism, coma & delirium tremens. Administer O-Morphon with extreme caution to patients with conditions accompanied by hypoxia, hypercapnia, or decreased respiratory reserve such as: asthma, chronic obstructive pulmonary disease or, severe obesity, sleep apnea syndrome, myxedema, kyphoscoliosis, CNS depression, or coma. O-Morphon, like all opioid analgesics, should be started at 1/3 to 1/2 of the usual dose in patients who are concurrently receiving other central nervous system (CNS) depressants including sedatives or hypnotics, general anesthetics, phenothiazines, tranquilizers, and alcohol, because respiratory depression, hypotension and profound sedation, coma or death may result. Use O-Morphon with caution in patients with mild hepatic impairment, starting with the lowest dose (e.g., 5 mg). The plasma levels of O-Morphon administered as an extended-release tablet were about 40% higher in elderly (=65 years of age) than in younger subjects. So for geriatric patients may be started with O-Morphon 5 mg. There are 57% and 65% increases in O-Morphon bioavailability in patients with moderate and severe renal impairment, respectively. So for renal impaired patients may be started with O-Morphon 5 mg. Use O-Morphon with caution in the following conditions: adrenocortical insufficiency (e.g., Addison's disease), prostatic hypertrophy or urethral stricture, severe impairment of pulmonary or renal function, and toxic psychosis Opioid analgesics impair the mental and physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery.Dependence: O-Morphon should not be abruptly discontinued. When the patient no longer requires therapywith O-Morphon, doses should be tapered gradually to prevent signs and symptoms of withdrawal in thephysically dependent patient.
Contraindications
Oxymorphone Hydrochloride (tablet and injection) should not be given to anyone with a known hypersensitivity to oxymorphone hydrochloride, to any of its other ingredients, or to morphine-type analgesics such as codeine. It is also contraindicated in patients with respiratory depression, acute or severe bronchial asthma, paralytic ileus, or moderate to severe hepatic impairment.