Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Angina Pectoris

Nitrofix SR is used to relieve an angina (chest pain) attack as it happens and to help prevent future attacks caused by coronary artery disease.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle, producing a vasodilator effect on both peripheral arteries and veins with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular enddiastolic pressure (pre-load). Arteriolar relaxation reduces systemic vascular resistance and arterial pressure (after-load).Nitroglycerin forms free radical nitric oxide (NO), which activates guanylate cyclase, resulting in an increase of guanosine 3’5’-monophosphate (cyclic GMP) in smooth muscle and other tissues. This eventually leads to dephosphorylation of myosin light chains, which regulates thecontractile state in smooth muscle and results in vasodilation.Absorption: Nitroglycerin is rapidly absorbed and is often used in emergency situations for this reason. Distribution: The volume of distribution of Nitroglycerin is 3 L/kg. Metabolism: Nitroglycerin is rapidly metabolized in the liver by hepatic enzymes to di-nitrates and mononitrates. Elimination: Nitroglycerin is excreted by the renal route, primarily as the 2 di-nitro-metabolites.

Pregnancy & Breastfeeding

Pregnancy & Breastfeeding: The safety of nitrates during pregnancy and breastfeeding has not been established, as there is no clear evidence to confirm it. For this reason, doctors should only prescribe nitrates to pregnant women or nursing mothers when they judge it truly necessary. It is also not known whether Nitroglycerin passes into breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Sublingual tablet: One tablet (0.5 mg) should be dissolved under the tongue as soon as an acute anginal attack begins. The dose may be repeated about every five minutes until relief is obtained. If pain continues after a total of 3 tablets taken within 15 minutes, prompt medical attention is recommended. Sustained release tablet: The dose should always be adjusted according to the individual patient's requirement, response and the severity of the anginal pain. 2.6 mg: 1 tablet 2 times a day before meals, in the morning and at noon. If necessary, the dose may be raised gradually to 2 or 3 tablets twice daily. 6.4 mg: One tablet twice daily, or as directed by the registered physician. Spray: At the onset of an attack, one metered dose spray or two metered dose sprays should be given under the tongue. A spray may be repeated about every 5 minutes as needed, up to a maximum of 3 metered sprays within a 15 minute period. If chest pain continues after a total of 3 sprays, prompt medical attention is recommended. It may also be used beforehand, 5 to 10 minutes ahead of activities that might bring on an acute attack.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.