Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Glaucoma Edema

Osmotic is principally used by IV infusion as an osmotic diuretic to preserve renal function in acute renal failure and to reduce raised intracranial and intraocular pressure. Osmotic is also used as an irrigating solution to prevent hemolysis and hemoglobin buildup during transurethral prostatic ... Read moreOsmotic is principally used by IV infusion as an osmotic diuretic to preserve renal function in acute renal failure and to reduce raised intracranial and intraocular pressure. Osmotic is also used as an irrigating solution to prevent hemolysis and hemoglobin buildup during transurethral prostatic resection. It is useful in the management of acute drug poisoning where a route of elimination is through kidney. Besides these, it is also used in symptomatic relief of edema, reperfusion injury, termination of pregnancy, and bowel preparation. So, Osmotic is indicated in- Renal insufficiency Reperfusion injury Raised intracranial pressure Bladder irrigation Raised intraocular pressure Bowel preparation Edematous status As a prophylactic in renal failure Management of poisoning Termination of Pregnancy

⚠️ Always consult a registered physician before taking any medicine.

Pregnancy & Breastfeeding

Safety of intravenous Mannitol during pregnancy has not been established. It is also not known whether mannitol passes into breast milk, so it should be used only after carefully weighing the potential benefits against the possible risks.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The adult dose of Mannitol ranges from 50 to 100 gm by IV infusion. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 ml/hr. Total dosage, concentration and the rate of administration depends on fluid requirement, urinary output and the severity of the condition being treated. For renal insufficiency, adults are given 50 to 100 g of Mannitol at a rate adjusted to maintain a urine flow of at least 30 to 50 ml/hr, while children are given 2 gm/kg or 60 gm/m2 of body surface area over a period of 2 to 6 hrs. For cerebral edema, elevated intracranial pressure, elevated intraocular pressure and glaucoma, adults are given 1.5 to 2 gm/kg over a period of 30 to 60 minutes, while children are given 1 to 2 gm/kg body wt. or 30 to 60 gm/m2 of body surface area over a period of 30 to 60 mins. As adjunctive therapy for removal of toxic substances, adults are given 50 to 200 g of Mannitol at a rate adjusted to maintain a urine flow of at least 100 to 500 ml/hr, while children are given 2 gm/kg or 60 gm/m2 of body surface area. For termination of pregnancy, 50 gm of Mannitol (250 ml of Mannitol) is instilled into the amniotic cavity, which induces abortion in a high proportion of pregnancies.