Indications
Lotepin T ophthalmic suspension is used for steroid-responsive inflammatory conditions of the eye where a corticosteroid is needed and where a superficial bacterial eye infection is present or there is a risk of one developing. Eye steroids are used for inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis and cyclitis. This medicine is also used for chronic anterior uveitis and for corneal injury caused by chemical, radiation or thermal burns, or by penetration of foreign bodies. Lotepin T is also used to treat post-operative inflammation following eye surgery.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Corticosteroids are believed to work by inducing phospholipase A2 inhibitory proteins, known collectively as lipocortins. These proteins are thought to control the production of powerful inflammatory mediators such as prostaglandins and leukotrienes by blocking the release of their shared precursor, arachidonic acid, which is normally released from membrane phospholipids by phospholipase A2. The antibiotic component, Tobramycin, is included to act against susceptible organisms. In vitro studies have shown Tobramycin to be active against susceptible strains of Staphylococci, including S. aureus and S. epidermidis (both coagulase-positive and coagulase-negative), including penicillin-resistant strains; Streptococci, including some Group A beta-hemolytic species, some nonhemolytic species, and some Streptococcus pneumoniae; Pseudomonas aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter aerogenes; Proteus mirabilis; Morganella morganii; most strains of Proteus vulgaris; Haemophilus influenzae and H. aegyptius; Moraxella lacunata; Acinetobacter calcoaceticus; and some Neisseria species.
Pregnancy & Breastfeeding
Pregnancy: This medicine falls under Pregnancy Category C. Adequate, well-controlled studies in pregnant women have not been conducted. It should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.
Lactation: It is not known whether topical ophthalmic use of corticosteroids leads to enough systemic absorption to produce detectable levels in human breast milk. Caution should be exercised when this medicine is given to a breastfeeding woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.