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Community data Updated 2 months ago

Lercanidipine Hydrochloride

Calcium-channel blockers Prescription
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Indications

Hypertension

Lotensyl is used to treat mild to moderate essential (primary) hypertension.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Lercanidipine is a dihydropyridine-type calcium channel blocker that acts selectively, reducing the flow of calcium into the smooth muscle cells lining blood vessels. It lowers blood pressure mainly by relaxing this vascular smooth muscle directly, which brings down overall resistance in the peripheral blood vessels. Because it partitions strongly into cell membranes, its blood-pressure-lowering effect lasts for an extended period, and its high selectivity for blood vessels means it does not weaken the force of the heart's contractions.

Pregnancy & Breastfeeding

Since there is no clinical data with Lercanidipine in pregnancy, it should not be administered during pregnancy or to woman with child bearing potential unless effective contraception is used. Lercanidipine is highly lipophilic and distribution in milk may be expected. Therefore, it should not be administered to nursing mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Use in the elderly: The usual starting dose is 10 mg by mouth once daily, taken at least 15 minutes before a meal. Depending on how the individual patient responds, this may be increased to 20 mg. It can take around 2 weeks for the full blood-pressure-lowering effect to become apparent. Patients whose blood pressure is not adequately controlled on a single antihypertensive may benefit from adding Lercanidipine to treatment with a beta-blocker (atenolol), a diuretic (hydrochlorothiazide), or an ACE inhibitor (ramipril). Use in children: There is no clinical data for patients under 18 years of age, so use in children is not currently recommended. Use in renal or hepatic impairment: Caution is needed in patients with mild to moderate kidney or liver impairment, and doses above 20 mg daily should be approached carefully. Lercanidipine is not recommended for patients with severe hepatic or renal impairment.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.