Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Depression

Imnoc is used to treat depressive illness, and to manage bedwetting at night (nocturnal enuresis) in children.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Imipramine works by slowing down the brain's reabsorption of two natural mood-regulating chemicals, norepinephrine and serotonin. It attaches to the transporter proteins responsible for pulling these neurotransmitters back into nerve cells, and by blocking this reuptake, it allows more of them to remain available at the junction between neurons. Depression has been associated with insufficient stimulation of nerve cells by norepinephrine and serotonin, so raising their levels at this junction is believed to trigger downstream changes in cell signalling pathways, gradually altering brain activity in ways that help ease depressive symptoms.

Pregnancy & Breastfeeding

Pregnancy category D. Limited evidence suggests imipramine passes into human breast milk. It is known to carry a risk of harming the developing fetus.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For depression, adults usually start with up to 75 mg a day, taken in divided doses, and the dose is then increased gradually to 150 to 200 mg a day (up to 300 mg a day for patients in hospital). A dose of up to 150 mg may be taken as a single dose at bedtime. Elderly patients start with 10 mg a day, increased gradually to 30 to 50 mg a day. This medicine is not recommended for children with depression. For bedwetting at night (nocturnal enuresis), children aged 7 to 8 years take 25 mg, children aged 8 to 11 years take 25 to 50 mg, and children over 11 years take 50 to 75 mg, all given at bedtime. The total period of treatment, including the gradual withdrawal at the end, should not exceed 3 months, and a full physical examination is needed before any further course is started.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.