Pricing
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Pinor is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For depression, adults usually start with up to 75 mg a day, taken in divided doses, and the dose is then increased gradually to 150 to 200 mg a day (up to 300 mg a day for patients in hospital). A dose of up to 150 mg may be taken as a single dose at bedtime. Elderly patients start with 10 mg a day, increased gradually to 30 to 50 mg a day. This medicine is not recommended for children with depression. For bedwetting at night (nocturnal enuresis), children aged 7 to 8 years take 25 mg, children aged 8 to 11 years take 25 to 50 mg, and children over 11 years take 50 to 75 mg, all given at bedtime. The total period of treatment, including the gradual withdrawal at the end, should not exceed 3 months, and a full physical examination is needed before any further course is started.
Side Effects
The most common side effects are dry mouth, constipation, difficulty passing urine, a faster heartbeat, drowsiness, irritability, dizziness, and reduced coordination. If dry mouth becomes severe enough to make speaking or swallowing difficult, it may be managed by lowering the dose or stopping the medicine for a short time. Imipramine has been linked to both rises and falls in blood pressure and heart rate. Heart attacks, congestive heart failure, and strokes have been reported. A small proportion of people taking imipramine have reported confusion, disorientation, delusions, sleeplessness, and anxiety. Skin-related problems (loss of sensation, numbness and tingling, rashes, spots, itching, and puffiness), seizures, and ringing in the ears have also been reported. In a small number of people, imipramine has been associated with nausea, vomiting, loss of appetite, diarrhoea, and abdominal cramps.
Cautions & Contraindications
Warnings & Precautions
Imnoc should be used with caution and under close medical supervision, particularly in elderly patients and in those with benign prostatic hypertrophy, urinary retention, or glaucoma (especially angle-closure glaucoma). Its sedative effect is increased when imipramine is taken together with other central nervous system depressants, such as alcohol, sleeping medicines, other sedatives, or antihistamines. Imnoc may raise the heart rate and place additional strain on the heart. Taking Imnoc, or any other antidepressant of the same pharmacological class, may be dangerous for people with cardiovascular disease, especially those who have recently had a heart attack. Elderly patients and those with a history of heart disease may develop arrhythmias, conduction abnormalities, congestive heart failure, heart attack, abnormally fast heart rates, or stroke. Patients starting imipramine should be closely monitored for signs of suicidal behaviour until a therapeutic dose has been established. The risk of suicide is higher when imipramine is taken in overdose or combined with alcohol. Manic episodes, as well as the emergence of symptoms in patients with pre-existing psychotic conditions, have been reported at the start of imipramine therapy.
Contraindications
Imipramine must not be given together with a monoamine oxidase (MAO) inhibitor, or within 14 days of stopping one. Combining these drugs can cause serious interactions, including hypertensive crises, hyperactivity, hyperpyrexia, spasticity, severe convulsions or coma, and death may occur. Imipramine is also contraindicated in patients with existing severe liver or kidney damage, and in those with a history of blood dyscrasias. It should not be given to patients who have shown hypersensitivity to imipramine or to tricyclic antidepressants of the dibenzazepine group. Imipramine is contraindicated during the acute recovery phase after a myocardial infarction (heart attack), and it should not be used in patients with convulsive disorders or glaucoma.