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Community data Updated 2 months ago

Hydroxychloroquine Sulphate

Anti-malarial drugs Prescription
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Indications

Rheumatoid Arthritis Malaria

Roxiquin is indicated for the treatment of acute and chronic rheumatoid arthritis, systemic lupus erythematosus (SLE), and malaria.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Hydroxychloroquine Sulphate is a synthetic version of quinine. It works as an immunosuppressant by reducing the body's production of rheumatoid factor and acute phase reactants. The drug also builds up inside white blood cells, where it stabilizes lysosomal membranes and blocks the activity of several enzymes, including collagenase and the proteases responsible for cartilage breakdown. Against malaria, it acts by disrupting the cell walls of infected red blood cells, killing the parasites as they develop.

Pregnancy & Breastfeeding

During pregnancy, use this drug only if clearly needed. Since small amounts pass into breast milk, consult your doctor before use.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Hydroxychloroquine Sulphate tablets are taken by mouth, and it's best to take them with food to help avoid an upset stomach. For acute and chronic rheumatoid arthritis, the usual dose is 400 to 600 mg daily; once a good response is achieved, which is usually within 4 to 8 weeks, the dose can be reduced to 50%. For Systemic Lupus Erythematosus (SLE), the dose is 400 mg once or twice daily for several weeks or months depending on how the patient responds, with a maintenance dose of 200 to 400 mg daily. For malaria in adults, an initial dose of 800 mg is given, followed by 400 mg after 6 to 8 hours, and then 400 mg on each of the next two consecutive days. In children, a total dose equal to 25 mg/kg is given over 3 days as follows: the first dose is 10 mg base/kg, not exceeding a single dose of 620 mg base; the second dose is 5 mg base/kg, not exceeding a single dose of 310 mg base, given 6 hours after the first dose; the third dose is 5 mg base/kg given 18 hours after the second dose; and the fourth dose is 5 mg base/kg given 24 hours after the third dose.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.