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Hydroxocobalamin

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Indications

Anemia

Cynomin-H is used for treating Addisonian pernicious anaemia, as well as for preventing and treating other macrocytic anaemias caused by vitamin B12 deficiency. It is also used in the Schilling test to assess vitamin B12 absorption and identify deficiency states.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Hydroxocobalamin (Vitamin B12) is a water-soluble vitamin. It is readily converted in the body into active coenzyme forms: as methylcobalamin, it takes part in converting homocysteine to methionine, and as deoxyadenosylcobalamin, in converting methylmalonyl-CoA to succinyl-CoA. These active coenzymes, methylcobalamin and 5-deoxyadenosylcobalamin, are essential for cell growth and replication.

Pregnancy & Breastfeeding

Hydroxocobalamin should not be used to treat megaloblastic anaemia occurring in pregnancy.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and children may use the following dosage schemes. For Addisonian pernicious anaemia and other macrocytic anaemias without neurological involvement: the initial dose is 250 to 1,000 micrograms by intramuscular injection on alternate days for one to two weeks, then 250 micrograms weekly until the blood count returns to normal. The maintenance dose is 1,000 micrograms monthly. For Addisonian pernicious anaemia and other macrocytic anaemias with neurological complications: the initial dose is 1,000 micrograms by intramuscular injection on alternate days for as long as improvement continues. The maintenance dose is 1,000 micrograms monthly. For prophylaxis of macrocytic anaemia associated with vitamin B12 deficiency arising from gastrectomy, certain malabsorption syndromes, or strict vegetarianism: 250 to 1,000 micrograms monthly. For the Schilling test: an intramuscular injection of 1,000 micrograms of hydroxocobalamin is an essential part of this test.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.