Glipizide + Metformin Hydrochloride
Indications
Metglip Plus is indicated as initial therapy, alongside diet and exercise, to improve blood sugar control in patients with type 2 diabetes whose high blood sugar cannot be adequately managed through diet and exercise alone. It is also indicated as second-line therapy for patients with type 2 diabetes whose blood sugar remains inadequately controlled after diet, exercise, and initial treatment with a Sulfonylurea or Metformin.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Metformin belongs to the biguanide class of antihyperglycemic medicines. It improves glucose tolerance in people with type 2 diabetes by lowering both fasting and after-meal blood glucose levels, working through mechanisms that differ from those of other oral antihyperglycemic drug classes. Metformin reduces glucose production by the liver, lowers glucose absorption from the intestine, and improves the body's sensitivity to insulin, allowing tissues to take up and use glucose more effectively. Unlike sulfonylureas, metformin does not cause hypoglycemia in patients with type 2 diabetes or in people without diabetes, and it does not raise insulin levels in the blood.
Glipizide is a sulfonylurea that lowers blood glucose mainly by stimulating the pancreas to release insulin, an action that depends on functioning beta cells in the pancreatic islets. Effects outside the pancreas may also contribute to how sulfonylurea drugs work.
Pregnancy & Breastfeeding
Contraindicated in pregnancy and during lactation
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.