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Other brands with the same active ingredient
These brands contain the same active ingredient (Glipizide + Metformin Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Pizide-X is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Glipizide & Metformin is usually taken once or twice a day with meals, starting at a low dose that is increased gradually as needed. For patients starting on Glipizide & Metformin as initial therapy, the usual starting dose is 250 mg/2.5 mg once daily with a meal. For patients switching to Glipizide & Metformin as second-line therapy, the usual starting dose is 500 mg/2.5 mg or 500 mg/5 mg twice daily, taken with the morning and evening meals. The daily dose should not exceed 2000 mg of Metformin and 20 mg of Glipizide.
Side Effects
Glipizide & Metformin most commonly cause hypoglycemia (low blood sugar), diarrhea, nausea/vomiting, abdominal pain, headache, and musculoskeletal pain, among others.
Cautions & Contraindications
Warnings & Precautions
Metformin is largely cleared by the kidneys, so the risk of it building up in the body and causing lactic acidosis rises as kidney function declines. For this reason, patients whose serum creatinine is above the normal upper limit should not be given Metformin. Because kidney function tends to decline with age, older patients need their Metformin dose carefully titrated to find the lowest amount that still controls blood glucose adequately. Metformin should be stopped temporarily before any surgical procedure, and should not be restarted until the patient is eating normally again and kidney function has been confirmed to be normal. When Metformin is used together with a sulfonylurea, blood glucose levels should be monitored closely. If Metformin is combined with insulin therapy, this should be managed in a hospital setting until the right balance between the two medicines has been worked out. In patients with reduced kidney or liver function, Glipizide may be broken down and cleared from the body more slowly. Should hypoglycemia occur in these patients, it may last longer than usual, and it should be managed appropriately.
Contraindications
Renal impairment, diabetic coma and ketoacidosis, chronic kidney disease, congestive heart failure, trauma, dehydration, alcohol dependence, pregnancy, and breast-feeding are contraindications, as is known hypersensitivity to the drug.