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Community data Updated 2 months ago

Glibenclamide

Sulfonylureas Prescription
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Indications

Type 2 Diabetes Mellitus Diabetes Mellitus

Suganil is used alongside a healthy diet and regular exercise to help adults with type 2 diabetes keep their blood sugar under control.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Glibenclamide appears to lower blood glucose in the short term by stimulating the pancreas to release insulin, an effect that depends on the beta cells in the pancreatic islets still functioning. How it lowers blood glucose with long-term use is not clearly understood. In Type 2 diabetes patients on chronic therapy, the blood-glucose-lowering effect continues even as the drug's ability to trigger insulin secretion gradually declines. Besides lowering blood glucose, Glibenclamide also produces a mild diuretic effect by increasing the kidneys' free water clearance.

Pregnancy & Breastfeeding

Pregnancy Category C. No specific data exist on Glibenclamide use during human pregnancy, but the medicine has been used widely for many years without any apparent harm being reported. Studies in animals have not shown any risk. Whether Glibenclamide passes into human breast milk is not yet known. Other sulphonylureas, however, do pass into breast milk, and there is no reason to think Glibenclamide behaves any differently in this regard.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: There is no single fixed dosage schedule for treating diabetes mellitus with Glibenclamide or with any other hypoglycemic medicine. As initial therapy, the usual starting dose is 2.5 to 5 mg daily, taken with breakfast or the first main meal of the day. Those patients who may be more sensitive to hypoglycemic drugs should begin at a lower dose of 1.25 mg daily. The usual maintenance dose falls in the range of 1.25 to 20 mg daily, and this may be taken as a single dose or split into divided doses. Any increase in dosage should be made in steps of no more than 2.5 mg, spaced at least a week apart, guided by the patient's blood glucose response. Daily doses above 20 mg are not recommended.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.