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Doxorubicin Hydrochloride

Cytotoxic Chemotherapy Prescription
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Indications

Cancer

Doxorubicin SDZ SDZ is indicated as part of multi-drug adjuvant chemotherapy for women whose axillary lymph nodes are involved, given after surgical removal of the primary breast cancer. It is also used to treat acute lymphoblastic leukemia, acute myeloblastic leukemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms' tumor, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma and metastatic bronchogenic carcinoma.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Doxorubicin hydrochloride is a cytotoxic anthracycline that inhibits topoisomerase II. The cytotoxic effect of Doxorubicin HCl on malignant cells, along with its toxic effects on various organs, is thought to stem from the drug's ability to intercalate between nucleotide bases and bind to cell membrane lipids. This intercalation blocks nucleotide replication and interferes with the action of DNA and RNA polymerases. The interaction of Doxorubicin with topoisomerase II to form DNA cleavable complexes appears to be an important mechanism behind the cytocidal activity of Doxorubicin HCl.

Pregnancy & Breastfeeding

Pregnancy Category D. Doxorubicin HCl can cause fetal harm when administered to a pregnant woman. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, apprise the patient of the potential hazard to a fetus. Female patients of reproductive potential should be advised to use highly effective contraception during treatment with Doxorubicin HCl and for 6 months after treatment. There is evidence of Doxorubicinbe excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Doxorubicin HCl, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Single agent: 60 to 75 mg/m2 given intravenously every 21 days.In combination therapy: 40 to 75 mg/m2 given intravenously every 21 to 28 days. Doxorubicin HCl should be discontinued in patients who develop signs or symptoms of cardiomyopathy, and dose should be reduced in patients with hepatic impairment. As an intravenous injection, Doxorubicin HCl is administered through a central intravenous line or a secure and free-flowing peripheral venous line containing 0.9% Sodium Chloride Injection, USP, 0.45% Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP over 3 to 10 minutes. The rate of Doxorubicin HCl administration should be decreased if erythematous streaking along the vein proximal to the site of infusion or facial flushing occur. As intravenous Infusion, Doxorubicin HCl is administered only through a central catheter.Management of Suspected Extravasation: Doxorubicin HCl should be discontinued in case of burning or stinging sensation or other evidence indicating perivenous infiltration or extravasation. Confirmed or suspected extravasation are managed as follows: The needle should not be removed until attempts are made to aspirate extravasated fluid The line should not be flushed Pressure should not be applied to the site Ice should be applied to the site intermittently for 15 min 4 times a day for 3 days If the extravasation is in an extremity, extremity should be elevated In adults, administration of dexrazoxane should be considered Incompatibility with Other Drugs: Doxorubicin hydrochloride should not be admixed with other drugs. If Doxorubicin HCl is mixed with heparin or fluorouracil a precipitate may form. Avoid contact with alkaline solutions which can lead to hydrolysis of Doxorubicin hydrochloride.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.