Indications
Predicot is used to treat inflammation and pain following eye surgery. It is also used to treat uveitis, pseudophakic cystoid macular oedema (CME), and ocular surface diseases such as blepharitis and corneal inflammation.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Corticosteroids reduce the inflammatory response to a variety of triggering agents and may delay or slow healing. They limit swelling, fibrin deposition, capillary dilation, movement of white blood cells into tissue, capillary proliferation, fibroblast proliferation, collagen deposition, and scar formation associated with inflammation. There is no generally accepted explanation for how ocular corticosteroids work. However, they are thought to act by inducing phospholipase A2 inhibitory proteins, collectively known as lipocortins. These proteins are believed to control the production of potent inflammatory mediators such as prostaglandins and leukotrienes by blocking the release of their shared precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by the enzyme phospholipase A2. Difluprednate is structurally similar to other corticosteroids.
Pregnancy & Breastfeeding
Pregnancy Category C. In animal studies, subcutaneous administration of Difluprednate to rabbits caused embryotoxic and teratogenic effects. Because its use during human pregnancy has not been studied, Difluprednate should be given to pregnant women only if the potential benefit outweighs the potential risk to the embryo or fetus. Whether Difluprednate passes into breast milk is not known, so caution is advised when it is used by nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.