Indications & Uses
Diflupred is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For inflammation and pain after eye surgery: put 1 drop into the conjunctival sac of the affected eye 4 times a day, starting 24 hours after surgery and continuing for the first 2 weeks after the operation. Then use 2 times a day for one week, and after that reduce the dose gradually depending on how the eye responds. For endogenous anterior uveitis: put 1 drop into the conjunctival sac of the affected eye 4 times a day for 14 days, then taper the dose as clinically indicated. For blepharitis: put 1 drop into the conjunctival sac of the affected eyes 2 times a day for 1 week, then once a day for 1 week. For pseudophakic cystoid macular oedema: put 1 drop into the conjunctival sac of the affected eyes 2 times a day.
Side Effects
Steroid eye drops, as a class, can cause a rise in pressure inside the eye, which may lead to damage to the optic nerve and loss of sharpness or areas of vision; clouding of the back of the lens (posterior subcapsular cataract); secondary eye infections caused by organisms such as herpes simplex; and, where the cornea or sclera is already thin, perforation of the eyeball. In patients treated with Predicot after eye surgery, the eye-related side effects reported included swelling of the cornea, redness of the ciliary body and conjunctiva, eye pain, sensitivity to light, clouding of the posterior lens capsule, cells and flare in the anterior chamber, swelling of the conjunctiva, and inflammation of the eyelids.
Cautions & Contraindications
Warnings & Precautions
Prolonged use of corticosteroids may lead to glaucoma and the formation of posterior subcapsular cataract. If Predicot is used for 10 days or longer, intraocular pressure (IOP) should be monitored. Great caution is required when corticosteroids are used to treat patients with a history of herpes simplex. Fungal infections of the cornea are particularly likely to develop alongside long-term local steroid use. Do not let the dropper tip touch any surface, as this may contaminate Predicot.
Contraindications
Difluprednate must not be used in most active viral infections of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella. It is also contraindicated in mycobacterial infections of the eye and in fungal infections of the eye's structures.