Indications
Healing of Erosive Esophagitis: Dexall is used to heal erosive esophagitis (EE) of any grade, with treatment continuing for up to 8 weeks. Maintenance of Healed Erosive Esophagitis: Once healing is achieved, Dexall can be continued for up to 6 months to keep EE healed and to prevent heartburn from returning. Symptomatic Non-Erosive Gastroesophageal Reflux Disease: Dexall is also used to relieve heartburn caused by symptomatic non-erosive GERD, taken for a course of 4 weeks.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Dexlansoprazole delayed-release capsule belongs to a class of medicines called proton pump inhibitors (PPIs). It reduces the amount of acid made by the stomach by specifically blocking the (H+/K+)-ATPase pump in the acid-producing cells of the stomach lining. Since this pump carries out the last step of acid production, targeting it directly shuts down acid release at its source.
Dexlansoprazole is the R-enantiomer of lansoprazole, which itself is a racemic mixture of R- and S-enantiomers. It is formulated as a Dual Delayed Release (DDR) capsule for oral use, containing two types of enteric-coated granules that dissolve at different pH levels. This design produces two separate absorption peaks in the blood: the first occurs 1 to 2 hours after taking the dose, and the second follows 4 to 5 hours after. After the medicine is taken by mouth, its peak blood concentration (Cmax) and overall exposure (AUC) rise roughly in proportion to the dose given. Dexlansoprazole is broken down mainly by the liver and leaves the body through urine.
Pregnancy & Breastfeeding
Pregnancy Category B. No adequate and well-controlled studies have looked at Dexlansoprazole's use in pregnant women, and the same is true for lactating mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.