Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Menstrual Disorder

Danazol is indicated for the following treatment: endometriosis, benign breast disease, menorrhagia, gynecomastia, and preoperative thinning of the endometrium before hysteroscopic endometrial ablation.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Danazol works as a gonadotropin inhibitor by suppressing the pituitary-ovarian axis, likely through reduced output of pituitary gonadotropins. It also blunts the preovulatory surge of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which lowers ovarian estrogen production. Danazol may directly inhibit ovarian steroidogenesis; it can bind to androgen, progesterone, and glucocorticoid receptors, as well as to sex-hormone-binding globulin and corticosteroid-binding globulin, and it raises the metabolic clearance rate of progesterone. It may also help endometriosis regress by lowering IgG, IgM, and IgA concentrations, along with phospholipid and IgG isotype autoantibodies.

In endometriosis, the suppression of ovarian function causes both normal and ectopic endometrial tissue to become inactive and atrophic, leading to anovulation and the associated amenorrhea. In fibrocystic breast disease, the exact mechanism is unknown, but it may relate to reduced estrogenic stimulation from decreased ovarian estrogen production; a direct effect on steroid receptor sites in breast tissue is also possible. This can lead to the disappearance of nodularity, relief of pain and tenderness, and sometimes changes in the menstrual pattern. For hereditary angioedema, danazol corrects the underlying biochemical deficiency by raising serum concentrations of the deficient C1 esterase inhibitor, which in turn increases serum concentrations of the C4 component of the complement system.

Pregnancy & Breastfeeding

Danazol should not be used during pregnancy: it can cause virilization in a female fetus, especially with high doses taken over several weeks. Women taking this medicine should also avoid breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Danazol is usually taken in up to 4 divided doses a day. Women who could become pregnant should start treatment during menstruation, preferably on the first day. For endometriosis: 200 to 800 mg daily in up to 4 divided doses, adjusted to stop menstrual periods, usually for 6 months (up to 9 months in some cases). For menorrhagia (heavy periods): daily doses of 100 to 200 mg have been found effective, but 200 mg daily for 3 months is usually enough to reduce menstrual blood flow to acceptable levels. For severe cyclical mastalgia (breast pain linked to the menstrual cycle): 100 to 400 mg daily, usually for 3 to 6 months. For benign breast cysts: 300 mg daily, usually for 3 to 6 months. For gynaecomastia: 400 mg daily in up to 4 divided doses for 6 months. In adolescents, 200 mg daily, increased to 400 mg daily if there is no response after 2 months. For pre-operative thinning of the endometrium: 400 to 800 mg daily in up to 4 divided doses for 3 to 6 weeks. Children: Danazol is not used in children.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.