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These brands contain the same active ingredient (Danazol). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Danamet is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Danazol is usually taken in up to 4 divided doses a day. Women who could become pregnant should start treatment during menstruation, preferably on the first day. For endometriosis: 200 to 800 mg daily in up to 4 divided doses, adjusted to stop menstrual periods, usually for 6 months (up to 9 months in some cases). For menorrhagia (heavy periods): daily doses of 100 to 200 mg have been found effective, but 200 mg daily for 3 months is usually enough to reduce menstrual blood flow to acceptable levels. For severe cyclical mastalgia (breast pain linked to the menstrual cycle): 100 to 400 mg daily, usually for 3 to 6 months. For benign breast cysts: 300 mg daily, usually for 3 to 6 months. For gynaecomastia: 400 mg daily in up to 4 divided doses for 6 months. In adolescents, 200 mg daily, increased to 400 mg daily if there is no response after 2 months. For pre-operative thinning of the endometrium: 400 to 800 mg daily in up to 4 divided doses for 3 to 6 weeks. Children: Danazol is not used in children.
Side Effects
Nausea, dizziness, skin reactions including rashes, photosensitivity and exfoliative dermatitis, fever, backache, nervousness, mood changes, anxiety, changes in libido, vertigo, fatigue, epigastric and pleuritic pain, headache, weight gain; menstrual disturbances, vaginal dryness and irritation, flushing and reduction in breast size; musculo-skeletal spasm, joint pain and swelling, hair loss; androgenic effects including acne, oily skin, oedema, hirsutism, voice changes and rarely clitoral hypertrophy; temporary alteration in lipoproteins and other metabolic changes, insulin resistance; thrombotic events; leucopenia, thrombocytopenia, eosinophilia, reversible erythrocytosis or polycythaemia reported; headache and visual disturbances may indicate benign intracranial hypertension.
Cautions & Contraindications
Warnings & Precautions
Use with caution in cardiac, hepatic or renal impairment, in elderly patients, and in those with polycythaemia, epilepsy, diabetes mellitus, hypertension, migraine, lipoprotein disorder, or a history of thrombosis or thromboembolic disease. If signs of virilization occur, such as voice changes or hirsutism, therapy should be stopped immediately.
Contraindications
Pregnancy and breast-feeding Impaired hepatic, renal, or cardiac function Porphyria Thromboembolic disease Androgen-dependent tumor Abnormal vaginal bleeding that has not been fully investigated. Hypersensitivity to danazol.