Indications
Dacarzin is used to treat metastatic malignant melanoma (melanoma that has spread). It is also used as a second-line treatment for Hodgkin's disease, in combination with other effective anticancer medicines.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Dacarbazine is a non-cell cycle specific antineoplastic agent. The exact mechanism of action by which it exerts cytotoxic effects is still unclear. However, three possible mechanisms have been postulated, including inhibition of DNA synthesis by acting as a purine analog, action as an alkylating agent, and interaction with sulfydryl group in the inhibition of bacterial cell growth.
Pregnancy & Breastfeeding
Pregnancy Category C. Dacarbazine for Injection has been shown to be teratogenic in rats when given at doses 20 times the human daily dose on day 12 of gestation. When male rats received 10 times the human daily dose of dacarbazine (twice weekly for 9 weeks), their libido was not affected, although female rats mated with these males showed a higher incidence of resorptions than controls. In rabbits, dacarbazine given at 7 times the human daily dose on Days 6 to 15 of gestation caused fetal skeletal anomalies. No adequate, well-controlled studies have been conducted in pregnant women. Dacarbazine for Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Whether this drug passes into human milk is not known. Because many drugs do pass into human milk, and given the tumorigenic potential Dacarbazine for Injection has shown in animal studies, a decision should be made to discontinue either nursing or the drug, taking into account how important the drug is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.