ইঙ্গিত
Dacarzin is used to treat metastatic malignant melanoma (melanoma that has spread). It is also used as a second-line treatment for Hodgkin's disease, in combination with other effective anticancer medicines.
⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।
ফার্মাকোলজি
Dacarbazine is a non-cell cycle specific antineoplastic agent. The exact mechanism of action by which it exerts cytotoxic effects is still unclear. However, three possible mechanisms have been postulated, including inhibition of DNA synthesis by acting as a purine analog, action as an alkylating agent, and interaction with sulfydryl group in the inhibition of bacterial cell growth.
Pregnancy & Breastfeeding
Pregnancy Category C. Dacarbazine for Injection has been shown to be teratogenic in rats when given at doses 20 times the human daily dose on day 12 of gestation. When male rats received 10 times the human daily dose of dacarbazine (twice weekly for 9 weeks), their libido was not affected, although female rats mated with these males showed a higher incidence of resorptions than controls. In rabbits, dacarbazine given at 7 times the human daily dose on Days 6 to 15 of gestation caused fetal skeletal anomalies. No adequate, well-controlled studies have been conducted in pregnant women. Dacarbazine for Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Whether this drug passes into human milk is not known. Because many drugs do pass into human milk, and given the tumorigenic potential Dacarbazine for Injection has shown in animal studies, a decision should be made to discontinue either nursing or the drug, taking into account how important the drug is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
ডোজ নির্দেশিকা
⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।
পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া
পার্শ্বপ্রতিক্রিয়া
No side-effect data recorded yet.